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MAXZIDE should not be given to patients receiving other potassium-conserving agents such as spironolactoneamiloride hydrochloride or other formulations containing triamtereneConcomitant potassium supplementation in the form of medicationpotassium-containing salt substitute or potassium-enriched diets should also not be used.
Triamterene is rapidly absorbed following oral administrationPeak plasma levels are achieved within one hour after dosingTriamterene is primarily metabolized to the sulfate conjugate of hydroxytriamtereneBoth the plasma and urine levels of this metabolite greatly exceed triamterene levels.
Triamterene is a weak folic acid antagonist and may contribute to the appearance of megaloblastosis in instances where folic acid stores are decreasedIn such patientsperiodic blood elevations are recommended.
In patients requiring hydrochlorothiazide therapy and in whom hypokalemia cannot be risked therapy may be initiated with MAXZIDE-25 MGIf an optimal blood pressure response is not obtained with MAXZIDE-25 MGthe dose should be increased to two MAXZIDE-25 MG tablets daily as a single doseor one MAXZIDE tablet dailyIf blood pressure still is not controlledanother antihypertensive agent may be addedsee PRECAUTIONSDRUG INTERACTIONS
Well controlled studies have demonstrated that doses of hydrochlorothiazide as low as 25 mg given once daily are effective in treating hypertensionbut the dose-response has not been clearly established.
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these products could cause your potassium levels to get too high while you are taking triamterene.
